产品货号：
Z17741
中文名称：
HDAC6抗体
英文名称：
Anti-HDAC6 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HDAC6 Antibody |
| 指标别名 | HD6;HDAC6;histone deacetylase 6;JM21;KIAA0901 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | HDAC6 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human HDAC6 (137-169aa EKEELMLVHSLEYIDLMETTQYMNEGELRVLAD),different from the related mouse sequence by one amino acid. |
| 实际分子量 | 160KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | HDAC6,also called KIAA0901,is a member belongs to class II of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC6 gene.The HDAC6 gene is mapped to chromosome Xp11.23.HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other.The protein possesses histone deacetylase activity and represses transcription.HDAC6 functions as a tubulin deacetylase.And it is localized exclusively in the cytoplasm,where it associates with microtubules and localizes with the microtubule motor complex.HDAC6 could bind both polyubiquitinated misfolded proteins and dynein motors,thereby recruiting misfolded protein cargo to dynein motors for transport to aggresomes.Furthermore,expression of HDAC6 was sufficient to rescue degeneration associated with UPS dysfunction in vivo in an autophagy-dependent manner.HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation. |
| Uniprot ID | Q9UBN7 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | histone deacetylase 6 |
| 蛋白名全称 | Histone deacetylase 6 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：HDAC6抗体，HDAC6多抗，Anti-HDAC6 Antibody